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Watt W. Webb     (WEB PAGE) drbio @ cornell.edu 223 Clark Hall      607-255-3331   [edit] Faculty Department: Applied and Engineering Physics Field: Applied Physics; Biochemistry, Molecular, and Cell Biology; Biomedical Engineering; Biophysics; Material Science and Engineering; Neurobiology and Behavior; Pharmacology Keywords: Cell and Molecular Neuroscience (23), Hippocampus (11), Mouse (11), Neurotransmitter receptors and transporters (9) The solution of seeming impossible experimental problems drives our creation of new experimental technologies for neuroscience, which during the past thirty years have focused primarily on observing the dynamics of the biomolecular processes of life. This challenge requires benign, effectively non-invasive methods that frequently push the physical limits of resolution in space, time and sensitivity. Several of these innovations: Multiphoton Microscopy (MPM), Fluorescence Correlation Spectroscopy (FCS), nanoscopic molecular tracking and most recently, nanostructured molecular dynamic probes are being applied to some of these seeming impossible biological problems. Over the years, about 35 of our publications have focused on the challenges of neuroscience, including: molecular mechanisms and physics of auditory transduction, the first successful single channel recording of reconstituted natural ion channels and on their structural fluctuations and mechano-sensitivity, signal delays along neural processes in neural networks, detection and imaging of serotonin and its secretion, imaging the development of the lesions of AlzheimerÌs Disease in transgenic mice, and most recently (now in press) successful optical imaging of action potentials with time resolutions corresponding to patch clamp recordings which promises to supplement the usual application of MPM to calcium signals as a method of choice for neural response measurements in live neural networks.

Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)