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  Showing all Detail for an individual

Barbara J. Strupp
    (WEB PAGE)		bjs13 @ cornell.edu
109 Savage Hall      607-255-2694		   [edit]

Faculty associated with: Stephane A. Beaudin,   Anna E. Beaudin,   Tara L. Benedetto
Department: Nutritional Sciences, Psychology
Field: Environmental Toxicology; Nutrition; Psychology

Keywords: Aging (6), Behavioral genetics (7), Cognitive Neuroscience (17), Genetics (9), Hippocampus (11), Learning and Memory (13), Mouse (11), Social behavior (12), Stress (8)

Neuroscience-related courses taught
Instructor: NS 361: Biology of Normal and Abnormal Behavior

In my lab, we are using rodent models to study human developmental cognitive disorders. This research is designed to identify the specific cognitive and affective processes that are affected and link these with underlying neural changes. The ultimate goals are to improve therapeutic intervention and elucidate basic brain-cognition relationships. Two projects, concerning prenatal cocaine exposure and early lead exposure, utilize rat models, whereas three other projects involve genetically manipulated mouse models of human disorders. These three projects deal with, respectively, mouse models of Down syndrome (the Ts65Dn mouse, which has a partial trisomy of chromosome 16),Fragile X syndrome (the fmr1 "knockout" mouse), and mice with a mutation in an enzyme involved in folate metabolism, to further investigate the role of folate alterations in neurogenesis and aging-related cognitive decline. We have recently discovered that perinatal supplementation with excess choline results in lasting cognitive benefits in the Down syndrome (DS) mouse model. This finding suggests that perinatal choline supplementation might significantly reduce the cognitive dysfunction seen in DS as well as reduce the risk of Alzheimer's Disease and age-related cognitive decline in the population at large. We are currently investigating the neural bases of this striking benefit.

Also visit my Research/Photo Gallery entry

Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)