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Linda M. Nowak     (WEB PAGE) lmn1 @ cornell.edu C3 117 Veterinary Medical Center      607-253-3655   [edit] Faculty Department: Molecular Medicine Field: Pharmacology Keywords: Cell and Molecular Neuroscience (23), Ligand-activated ion channels (2), Mathematical Modeling (14), Neurotransmitter receptors and transporters (9), Patch clamp (2) Neuroscience-related courses taught Instructor: VETMM 704: CNS Synaptic Transmission Instructor: VETMM 720: Patch Clamp Methods in Biology Members of my laboratory are studying excitatory amino acid (EAA) or "glutamate" activated receptor-channels in the vertebrate central nervous system. The principal approach to these investigations involves recordings of EAA activated receptor-channels in mammalian brain neurons in primary culture and recombinant receptor-channels expressed in mammalian cell lines and in Xenopus oocytes. Single channel recordings are employed to determine basic biophysical parameters of receptor channel function. Hidden Markov models are develpoed to model channel opening and closing rates. Chimeric cross-family subunit proteins are designed to study channel ion selectivity, gating, and receptor trafficking. Whole cell voltage-clamp recordings are also combined with single cell molecular biology methods in an effort to ascertain the likely subunit compositions of pharmacologically and biophysically distinct receptor-channel subtypes observed in cerebellar granule neurons and cerebral cortical neurons.

Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)