Program People Events Contact Site Index Printer Friendly

  Showing all Detail for an individual

Gregory A. Weiland     (WEB PAGE) gaw2 @ cornell.edu C3 147 VMC      607-253-3876   [edit] Faculty Department: Molecular Medicine Field: Comparative Biomedical Sciences; Neurobiology and Behavior; Pharmacology Keywords: Cell and Molecular Neuroscience (23), Ion channel (6), Neuromodulation (12), Neurotransmitter receptors and transporters (9), Proteins (3) Neuroscience-related courses taught Instructor: VETMM 703: Receptor-Ligand Interactions My general research interest is in the modulation of receptor properties by neurotransmitters and drugs. Currently we are studying the mechanisms of modulation of the nicotinic cholinergic receptor by its neurotransmitter acetylcholine and by the neuropeptide substance P. Nicotinic receptor responsiveness is regulated by acetylcholine and other cholinergic agonists via desensitization. In fact there are several desensitization processes each of which occurs on a different time scale, ranging from milliseconds to several minutes. Nicotinic receptor responsiveness also appears to be regulated physiologically by substance P, an eleven amino acid peptide that inhibits nicotinic receptor activation. One reason we have focused on both of these modulatory mechanisms is that they appear to be interrelated since at least part of the inhibition by substance P seems to be mediated by an increase in the rate and extent of desensitization. For more information, follow the web link above.

Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)