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  Field:    Environmental Toxicology - Web

    Full list of Fields at the bottom of the page

Barbara J. Strupp
    (WEB PAGE)		bjs13 @ cornell.edu
109 Savage Hall      607-255-2694		   [edit]

Faculty associated with: Stephane A. Beaudin,   Anna E. Beaudin,   Tara L. Benedetto

Keywords: Aging (6), Behavioral genetics (7), Cognitive Neuroscience (17), Genetics (9), Hippocampus (11), Learning and Memory (13), Mouse (11), Social behavior (12), Stress (8)

In my lab, we are using rodent models to study human developmental cognitive disorders. This research is designed to identify the specific cognitive and affective processes that are affected and link these with underlying neural changes. The ultimate goals are to improve therapeutic intervention and elucidate basic brain-cognition relationships. Two projects, concerning prenatal cocaine exposure and early lead exposure, utilize rat models, whereas three other projects involve genetically manipulated mouse models of human disorders. These three projects deal with, respectively, mouse models of Down syndrome (the Ts65Dn mouse, which has a partial trisomy of chromosome 16),Fragile X syndrome (the fmr1 "knockout" mouse), and mice with a mutation in an enzyme involved in folate metabolism, to further investigate the role of folate alterations in neurogenesis and aging-related cognitive decline. We have recently discovered that perinatal supplementation with excess choline results in lasting cognitive benefits in the Down syndrome (DS) mouse model. This finding suggests that perinatal choline supplementation might significantly reduce the cognitive dysfunction seen in DS as well as reduce the risk of Alzheimer's Disease and age-related cognitive decline in the population at large. We are currently investigating the neural bases of this striking benefit.

Also visit my Research/Photo Gallery entry
Tara L. Benedettotlb35 @ cornell.edu
104 Savage Hall      607-255-8378		   [edit]

Graduate Student associated with: Stephane A. Beaudin,   Barbara J. Strupp

Keywords: Developmental Neurotoxicology (2), Neurotransmitter receptors and transporters (9)

I am currently examining the long-lasting cognitive effects of prenatal cocaine exposure. I am specifically interested in how drug-induced neurochemical changes result in altered attentional set-shifting abilities. I hope to use a combination of neurological analyses and behavioral testing to develop possible therapeautic agents.

Stephane A. Beaudinsb94 @ cornell.edu
106 Savage Hall      607-255-5803		   [edit]

Research Associate associated with: Tara L. Benedetto,   Barbara J. Strupp

Keywords: Developmental Neurotoxicology (2), Learning and Memory (13), Systems Neuroscience (25)

My current research interests are in the field of developmental neurotoxicology or neurobehavioral teratology. Ongoing projects focuse on characterizing at both the neurobehavioral and neurochemical levels the enduring impairments resulting from prenatal IV cocaine exposure with the goal of developing and validating pharmacological interventions. Other interests include neurobehavioral studies pertaining to the lasting effects of early low-levels lead exposure and its treament with the chelating agent succimer.


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Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)