![]() ![]() | |||||||
| |||||||
|
Name, Field, Position, Department, and Keyword |
Faculty associated with: Ashok Gopinath,   Eric Williams Keywords: Axon guidance (3), Cell and Molecular Neuroscience (23), Development (21), Genetics (9), Mouse (11), Neurogenesis (7), Olfaction (11), Sensorimotor Systems (11) My lab is interested in the development of the mouse olfactory system. How are millions of olfactory sensory neurons in the nose able to find their appropriate targets in the olfactory bulb? We use molecular and genetic tools to understand this process of axon guidance and target recognition. The olfactory system is also one of the few systems that undergo regeneration in the adult animal. Are the same mechanisms and molecules used during regeneration as during development? By understanding this process in the embryo may provide insight into how regeneration is maintained during adulthood. |
![]()
Faculty Keywords: Cell and Molecular Neuroscience (23), Ion channel (6), Neuromodulation (12), Neurotransmitter receptors and transporters (9), Proteins (3) My general research interest is in the modulation of receptor properties by neurotransmitters and drugs. Currently we are studying the mechanisms of modulation of the nicotinic cholinergic receptor by its neurotransmitter acetylcholine and by the neuropeptide substance P. Nicotinic receptor responsiveness is regulated by acetylcholine and other cholinergic agonists via desensitization. In fact there are several desensitization processes each of which occurs on a different time scale, ranging from milliseconds to several minutes. Nicotinic receptor responsiveness also appears to be regulated physiologically by substance P, an eleven amino acid peptide that inhibits nicotinic receptor activation. One reason we have focused on both of these modulatory mechanisms is that they appear to be interrelated since at least part of the inhibition by substance P seems to be mediated by an increase in the rate and extent of desensitization. For more information, follow the web link above. |
Please report corrections, questions, comments, and problems to: Lori Miller (lmm8 AT cornell.edu)